John Mulaney and wife Anna Marie Tendler are divorcing

Comedian John Mulaney and his artist wife of six years, Anna Marie Tendler, are divorcing following his stay in rehab.

Sources tell us that Mulaney, who checked himself into rehab for 60 days late last year after struggling with alcohol and drug abuse, asked for a divorce from Tendler three months ago.

A spokesman for Mulaney confirmed the divorce to Page Six and added, “John will not have any further comment as he continues to focus on his recovery and getting back to work.”

Tendler — an artist who works across many mediums and is a master’s candidate in NYU’s Costume Studies program — added through her spokesperson, “I am heartbroken that John has decided to end our marriage.

“I wish him support and success as he continues his recovery.”

In December, the “Big Mouth” star, 38, entered a rehab facility in Pennsylvania for 60 days for treatment for cocaine and alcohol addiction, Page Six exclusively reported. In February, he exited the program and entered outpatient care.

“John has completed 60 days in rehab, and now he’s in outpatient sober care. He is doing well, although he is still not ready to return to work,” a source told Page Six at the time.

Then earlier this month, Mulaney announced his first set of tour dates after spending time in rehab. The comedian is doing a five-day residency called “John Mulaney: From Scratch” at Manhattan’s City Winery from May 10 to May 14.